
Using Recombinant Adenovirus for Successful Gene Delivery
Manuel
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Using adenovirus to deliver genes to target cells is an option for researchers who are interested in a high titer virus with high transient expression levels that infect a wide range of cell types. Although adenovirus does not integrate into the genome of the target cell the way a retrovirus can, it is an excellent choice when only transient…
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Adeno-Associated Virus (AAV) Provides Advantages for Gene Delivery
Manuel
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Recombinant Adeno-associated virus (AAV) is often the preferred method for delivering genes to target cells due to its high titer, mild immune response, ability to infect a broad range of cells, and overall safety. Native AAV can infect humans and primates; however, it has not been reported to cause disease and poses minimal risk to humans. Compared with…
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Methods for Measuring Cell Proliferation
Manuel
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Cell proliferation is an increase in the number of cells resulting from the normal, healthy process by which cells grow and divide. In this regard, cell proliferation can be a good indicator of general cell health. Cells that are subject to a variety of disease states may exhibit different rates of proliferation than normal cells. Therefore,…
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Measuring Cellular Hypoxia
Manuel
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Hypoxia, or low oxygen condition, is a normal physiological response to certain body stressors such as high altitudes. Such a condition can result in dizziness, light-headedness, nausea, and related reactions. These reactions may be a result of hypoxic conditions at the system level or the cellular level or both. Cellular hypoxia can also be a…
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